Kahsai, Alem W. : rechercher sur Z-Library

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1

Mechanism of β 2 AR regulation by an intracellular positive allosteric modulator

Liu, Xiangyu, Masoudi, Ali, Kahsai, Alem W., Huang, Li-Yin, Pani, Biswaranjan, Staus, Dean P., Shim, Paul J., Hirata, Kunio, Simhal, Rishabh K., Schwalb, Allison M., Rambarat, Paula K., Ahn, Seungkirl

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 848 KB

english, 2019

2

Quinocarmycin Analog DX-52-1 Inhibits Cell Migration and Targets Radixin, Disrupting Interactions of Radixin with Actin and CD44

Alem W. Kahsai, Shoutian Zhu, Duncan J. Wardrop, William S. Lane, Gabriel Fenteany

Journal:

Chemistry & Biology

Année:

2006

Langue:

english

Fichier:

PDF, 381 KB

english, 2006

3

G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells

Alem W. Kahsai, Shoutian Zhu, Gabriel Fenteany

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

2010

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2010

4

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K., Gawron, Sylwia, Sassano, Maria F., Kahsai, Alem W., Wingler, Laura M., Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnar

Journal:

ACS Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 438 KB

english, 2013

5

Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry

Kahsai, Alem W, Rajagopal, Sudarshan, Sun, Jinpeng, Xiao, Kunhong

Journal:

Nature Protocols

Année:

2014

Langue:

english

Fichier:

PDF, 1.40 MB

english, 2014

6

Multiple ligand-specific conformations of the β2-adrenergic receptor

Kahsai, Alem W, Xiao, Kunhong, Rajagopal, Sudarshan, Ahn, Seungkirl, Shukla, Arun K, Sun, Jinpeng, Oas, Terrence G, Lefkowitz, Robert J

Journal:

Nature Chemical Biology

Année:

2011

Langue:

english

Fichier:

PDF, 1.87 MB

english, 2011

7

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

Kahsai, Alem W, Wisler, James W, Lee, Jungmin, Ahn, Seungkirl, Cahill III, Thomas J, Dennison, S Moses, Staus, Dean P, Thomsen, Alex R B, Anasti, Kara M, Pani, Biswaranjan, Wingler, Laura M, Desai, He

Journal:

Nature Chemical Biology

Année:

2016

Langue:

english

Fichier:

PDF, 1.80 MB

english, 2016

8

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Staus, Dean P., Strachan, Ryan T., Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W., Kim, Tae Hun, Wingler, Laura M., Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C., Pardon, Els

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 4.52 MB

english, 2016

9

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

Thomsen, Alex R.B., Plouffe, Bianca, Cahill, Thomas J., Shukla, Arun K., Tarrasch, Jeffrey T., Dosey, Annie M., Kahsai, Alem W., Strachan, Ryan T., Pani, Biswaranjan, Mahoney, Jacob P., Huang, Liyin,

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 3.48 MB

english, 2016

10

receptor

Kahsai, Alem W, Xiao, Kunhong, Rajagopal, Sudarshan, Ahn, Seungkirl, Arun, K

Année:

2012

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2012

11

Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library

Ahn, Seungkirl, Kahsai, Alem W., Pani, Biswaranjan, Wang, Qin-Ting, Zhao, Shuai, Wall, Alissa L., Strachan, Ryan T., Staus, Dean P., Wingler, Laura M., Sun, Lillian D., Sinnaeve, Justine, Choi, Minjun

Journal:

Proceedings of the National Academy of Sciences

Année:

2017

Langue:

english

Fichier:

PDF, 934 KB

english, 2017

12

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

Cahill, Thomas J., Thomsen, Alex R. B., Tarrasch, Jeffrey T., Plouffe, Bianca, Nguyen, Anthony H., Yang, Fan, Huang, Li-Yin, Kahsai, Alem W., Bassoni, Daniel L., Gavino, Bryant J., Lamerdin, Jane E.,

Journal:

Proceedings of the National Academy of Sciences

Année:

2017

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2017

13

Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure

Liu, Xiangyu, Ahn, Seungkirl, Kahsai, Alem W., Meng, Kai-Cheng, Latorraca, Naomi R., Pani, Biswaranjan, Venkatakrishnan, A. J., Masoudi, Ali, Weis, William I., Dror, Ron O., Chen, Xin, Lefkowitz, Robe

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 7.48 MB

english, 2017

14

Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β 2 -adrenergic receptor

Meng, Kaicheng, Shim, Paul, Wang, Qingtin, Zhao, Shuai, Gu, Ting, Kahsai, Alem W., Ahn, Seungkirl, Chen, Xin

Journal:

Bioorganic & Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2018

15

Small Molecule Positive Allosteric Modulators of the β 2 -Adrenoceptor Isolated from DNA Encoded Libraries

Ahn, Seungkirl, Pani, Biswaranjan, Kahsai, Alem W., Olsen, Eva K., Husemoen, Gitte, Vestrgaard, Mikkel, Jin, Lei, Zhao, Shuai, Wingler, Laura M., Rambarat, Paula K., Simhal, Rishabh K., Xu, Thomas T.,

Journal:

Molecular Pharmacology

Année:

2018

Langue:

english

Fichier:

PDF, 3.94 MB

english, 2018

16

GPCR signaling: conformational activation of arrestins

Kahsai, Alem W., Pani, Biswaranjan, Lefkowitz, Robert J.

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 549 KB

english, 2018